naltrexone injection half life
Naltrexones half-life is 4 h and it is a highly metabolized 98 drugthe major metabolite being 6-β-naltrexol with a half-life of 13 h and antagonist action on opioid receptors. The volume of distribution is 4 Lkg where 8 to 19 of the drug is protein bound.
Naltrexone Naltrexone Bupropion Combination Mechanism Of Action
Glomerular filtration is the predominant mode of renal elimination for a small fraction of unmetabolized naltrexone while 6-β-naltrexol is additionally secreted.
. The residual unchanged form gets excreted in. Half-life is approximately 11 hours but varies between 8 to 15 hours. Excretion is mainly through urine in the glucuronidated form.
Metabolism occurs in the liver through glucuronidation where most of it converts to hydromorphone-3-glucuronide.
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